Santa Ana is a city in the Los Angeles metropolitan area and the county seat of Orange County, California. The City is the county's second most populous. The projected population is in excess of 332,000. Thus, it makes Santa Ana the 57th most populous city in the USA. Santa Ana is situated about 10 miles from the coast, in southern California, adjacent to the Santa Ana River. Santa Ana is named after the Santa Ana Freeway (I-5), which runs through the area. It shares its name with the surrounding mountains of Santa Ana too. It has an area of 27 miles.