Port St. Lucie is a city located in St. Lucie County, United States, Florida. With a population of over 160,000, it is the most populous municipality in the county. It is 125 miles southeast from Orlando and 114 miles northwest from Miami. Port St. Lucie also falls within the areas of Miami and Fort Lauderdale. The city is home to spring training for the New York Mets. Its surface area is 120 miles.